– Diagnosis: Diffuse subdural hematomas of multiple ages (convexities, parafalcine, tentorium) But more important:
– Diffuse swelling of gyri and edema with effacement of the CSF-containing spaces
– Diffuse loss of normal grey-white differentiation
– Decreased bilateral basal ganglia attenuation
– = Sequelae of traumatic brain injury (TBI) indicating hypoxic-ischemic injury, with poor prognostic outcome. Patient died several hours later
– Note: We do not see here the reversal sign (reversal of the normal CT attenuation of grey and white matter) or white cerebellum sign (diffuse oedema and hypoattenuation of the cerebral hemispheres with sparing of the cerebellum and brainstem, resulting in apparent high attenuation of the cerebellum and brainstem relative to the cerebral hemispheres)
60-year-old female:
– Since a few weeks eye movement disorder and diplopia of the left eye, tinnitus, and sinusitis.
– Non-enhanced CT of the orbits is performed (due to contrast allergy).
What are your findings?
Widened infraorbital canal left eye with thickening of the infraorbital nerve.
What is your differential diagnosis and do you want more imaging?
Yes, we want MRI to sort things out more.
Findings: Smoothly thickened T2 hyperintense, enhancing infraorbital nerve in its canal. No continuation posteriorly to the vidian canal or anteriorly to the pre-antral region. No pathologic paranasal sinus mass or pharyngeal mucosal mass indicating perineural tumor spread.
Differential diagnosis:
Schwannoma.
Less likely malignant cause like perineural tumour spread.
Biopsy is performed of right lacrimal gland, since clinically this was found to be prominent (radiologically slight asymmetry, slightly higher T2 signal).
Histopathology: IgG4 disease or dacryoadenitis.
After this, whole body scanning showed evidence of IgG4 disease in the pancreas also. Patient was treated with steroids.
Follow-up MRI: Decrease in size of the infraorbital nerve from 11 to 5 mm. Still high T2 signal, however, the decrease in size on steroids suggests other diagnosis than schwannoma, in this case probably involved in orbital IgG4 disease. Rare!
61-year-old female:
– Trauma
– Fracture? What do you see?
Showing the supine AP and lateral view, due to the inability to stand on the right leg.
Click here to see the answer
Diagnosis: Lipohemarthrosis (fat-blood level) indicating intra-articular #
Comminutive though non-displaced tibia plateau fracture Avulsion fracture proximal fibula (Segond fracture – 100% association with ACL injury)
CT: Schatzker type VI
Schatzker tibia plateau classification
– Schatzker I:wedge-shaped pure cleavage fracture of the lateral tibial plateau, having less than 4 mm of depression or displacement
– Schatzker II:splitting and depression of the lateral tibial plateau; namely, type I fracture with a depressed component
– Schatzker III:pure depression of the lateral tibial plateau; divided into two subtypes:
– Schatzker IIIa: with lateral depression
– Schatzker IIIb: with central depression
– Schatzker IV:medial tibial plateau fracture with a split or depressed component
– Schatzker V: wedge fracture of both lateral and medial tibial plateau
– Schatzker VI:transverse tibial metadiaphyseal fracture, along with any type of tibial plateau fracture (metaphyseal-diaphyseal discontinuity)
54-year-old woman:
– Known breast cancer
– Arm paresis and soft-tissue lump
What are the salient findings?
Left: NECT, bone algorithm. Aggressive-like bone lesion with permeative pattern and hair on end periosteal reaction
Right: MRI T1 post-Gd. Associated trans-diploic soft-tissue mass with extracranial and intracranial-extraaxial components. Solid, homogeneous and avidly enhancing. Contiguous dural thickening and enhancement.
What is the differential diagnosis?
DIFFERENTIAL DIAGNOSIS FOR TRANS-DIPLOIC SKULL VAULT LESION WITH AGGRESSIVE-LIKE BONE AFFECTATION
– Always consider in older patients
– Multiplicity and known primary
Imaging
Varies depending on tumor type and aggressiveness
– Lytic: Most tumor types
– Permeative: Highly cellular and small-round cell tumors (PNET, small cell lung, lymphoma)
– Sclerotic/mixed: Prostate, breast. Less frequently: Transitional cell, neuroendocrine, PNET
– Hypervascular: Renal cell, melanoma, thyroid, hepatocarcinoma, lung, neuroendocrine
Possible soft-tissue components
LYTIC AGGRESSIVE BONE LESION/S IN PATIENT >40 years old. METASTASES vs MYELOMA
MULTIPLE MYELOMA (MM)/SOLITARY PLASMOCYTOMA
MULTIPLE MYELOMA (MM)/SOLITARY PLASMOCYTOMA
– Affects older patients (median 68-70 years). Very rare under 40 years (<10%)
Imaging
MM 4 patterns of bone involvement
– Diffuse lytic bone infiltration simulating osteopenia
– Multiple focal lytic well-defined lesions
– Solitary plasmacytoma
– Sclerotic bone lesions (exclusively associated with POEMS sd)
Solitary plasmacytoma in the skull: lytic, aggressive trans-diploic, soft tissues, and hypervascular aspect
CLASSIC APPEARANCE OF MM CLASSIC APPEARANCE OF SOLITARY PLASMOCYTOMA OF THE SKULLLYMPHOMA
LYMPHOMA
– 7% of all bone malignancy; 5% of extranodal lymphoma
– All ages; predominates in adults (peak 50-60 years); men/women 1.5:1
– Secondary dissemination >>> primary bone lymphoma
– Imaging characteristics of a hypercellular small round cell tumour
Imaging
– Trans-diploic permeative bone pattern and abundant of tissue components (small round blue cells spread through Haversian canals conditioning a striking relatively little bone destruction in comparison to important soft-tissue lesions)
– Hyperdensity on NECT, T2 hypodensity and striking diffusion restriction on DWI (all signs related to hypercellularity)
– Homogenous enhancement
– No or little necrosis
CHARACTERISTIC IMAGING FINDINGS FOR LYMPHOMAOSTEOSARCOMA
OSTEOSARCOMA
– Most common primary high-grade bone sarcoma
– Bimodal distribution: 10-14 and >40 years old
– Extremely rare in the skull in adults, and much more frequently arising from coexisting Paget’s disease> >previously irradiated bone> or bone infarction
– Clinically, quickly growing painful mass
Imaging
– Destructive, aggressive lesion, with periosteal reaction, soft tissue-mixed lytic-blastic component. May show “fluffy”, “cloud-like” osteoid matrix.
Secondary osteosarcoma arising in a Pagetic skull. See the globally aggressive pattern and the deep hypointensities inside the soft-tissue components probably transducing osteoid matrix (usually easily depicted on CT, non-available in this case)
MENINGIOMA
MENINGIOMA
– Most common brain tumor (36% of all brain tumors)
– Predilection for middle-aged females
– Can produce neurologic symptoms due to compression
– Most do not infiltrate bone, but when they do it, the hyperostosis is very specific, virtually pathognomonic
– Intra-diploic or trans-diploic meningiomas are less frequent
*Even the great specificity of the hyperostosis, bone involvement can be VERY VARIABLE including aggressive-like lysis and periosteal reactions that do not exclude or go against the diagnostic
Ddx: Hemangiopericytoma (Solitary Fibrous Tumor New WHO 2016 classification). Younger, frequently male patients. Osteolysis possible, but NO hyperostosis. NO calcifications. The rest of imaging features identical to meningioma, differentiation is very difficult and challenging
EXAMPLES OF THE MULTIPLE FACES OF MENINGIOMAS AND THEIR BONE INVOLVEMENT. REMEMBER, POLYMORPHISM IS AN IMPORTANT FEATURE OF THIS ENTITY
With all the information mentioned above:
Could meningiomas condition aggress periosteal reaction? Does it go against its diagnosis
Meningiomas are very frequent, specially in middle-aged woman, if all or the vast majority of features favour this diagnosis, a relatively atypical bone affectation (lysis, periosteal reaction instead of the virtually pathognomonic hyperostosis) may not change the diagnostic orientation.
Bonus clues and some advance imaging pearls
Diffusion: Striking restriction in lymphomas Perfusion: Striking high rCBV in meningiomas Spectroscopy: Alanine (and GLX) in meningiomas. Striking high Cho in lymphoma and plasmacytoma. Striking high lipids in metastases
Back to the case:
ARE THE ADVANCED IMAGING TECHNIQUES HELPFUL?
FINAL DIAGNOSIS: MENINGIOMA (WHO GRADE 2)
TAKE HOME MESSAGE REGARDING MENINGIOMA
– Very frequent, specially middle-aged women
– Important to know the classic characteristic features, some of them are very specific; but recognize the great polymorphism/many faces of this entity
– Advanced imaging can be helpful
– Not all the lesions in a neoplastic patient are metastases
– 66-year-old female:
– Feels a lump in the neck when swallowing
In what space houses this lesion?
Mass in the right parapharyngeal space or deep part of parotid space. No parapharyngeal fat is visible, so either the lesion displaces the fat or it arises from it. It is certainly not from the carotid space, since the carotid arteries are displaced posteriorly. It is also not from the mucosal space since it compresses the lateral oropharyngeal wall, instead of arising from it.
Do you want further imaging to make a diagnosis and what?
MRI will provide you more details in head and neck lesions where the lesion arises from exactly, and what the origin is. MRI is made with T1, T2, and T1 with Gad and fat suppression.
What is your differential diagnosis?
Origin from deep parotid lobe, so DD benign or malignant salivary gland tumor, such as pleiomorphic adenoma, adenoid cystic of mucoepidermoid cell carcinoma. Radiologists are not good in differentiating benign from malignant lesions on MRI. Histopathology has to be done. DWI will help you a little, in that, malignant lesions have often lower ADC values, but also Wharthin tumors do so. DD rare schwannoma arises from V3 (mandibular nerve) in the true parapharyngeal space.
Solution
We performed ultrasound and cytologic punction. This turned out to be a fairly rare acinic cell carcinoma.
Teaching point: Malignant tumors of the salivary glands are well delineated and do not have to present as ill-defined lesions, nor have to have lymph node metastasis or perineural spread.
Sclerotic lesion arising from the outer layer of the left parietal bone with narrow zone of transition. No cortical break through or soft tissue component. The medullary cavity is intact
Diagnosis: Sigmoid diverticulitis, no signs of complications/perforation such as air bubbles outside bowel lumen or paracolic abscess. Reactive bowel wall thickening (always be aware of underlying carcinoma!)
Name the three coincidental findings:
1. Gall stones
2. Right adrenal mass, DD metastasis from 3. or adenoma
3. Right interpolar solid mass, suspect for renal cell carcinoma
66-year-old female:
– Feels a lump in the neck when swallowing
In what space houses this lesion?
Mass in the right parapharyngeal space or deep part of parotid space. No parapharyngeal fat is visible, so either the lesion displaces the fat or it arises from it. It is certainly not from the carotid space, since the carotid arteries are displaced posteriorly. It is also not from the mucosal space since it compresses the lateral oropharyngeal wall, instead of arising from it.
Do you want further imaging to make a diagnosis and what?
MRI will provide you more details in head and neck lesions where the lesion arises from exactly, and what the origin is. MRI is made with T1, T2, and T1 with Gad and fat suppression.
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What is your differential diagnosis?
Origin from deep parotid lobe, so DD benign or malignant salivary gland tumor, such as pleiomorphic adenoma, adenoid cystic of mucoepidermoid cell carcinoma. Radiologists are not good in differentiating benign from malignant lesions on MRI. Histopathology has to be done. DWI will help you a little, in that, malignant lesions have often lower ADC values, but also Wharthin tumors do so. DD rare schwannoma arises from V3 (mandibular nerve) in the true parapharyngeal space.
We performed ultrasound and cytologic punction. This turned out to be a fairly rare acinic cell carcinoma.
Teaching point:
Malignant tumors of the salivary glands are well delineated and do not have to present as ill-defined lesions, nor have to have lymph node metastasis or perineural spread
